diff --git a/library/core/src/lib.rs b/library/core/src/lib.rs
index 35f93d8fb33b2..52813826d5f3b 100644
--- a/library/core/src/lib.rs
+++ b/library/core/src/lib.rs
@@ -385,3 +385,53 @@ pub mod simd {
 }
 
 include!("primitive_docs.rs");
+
+// Global metadata markers for the Enzyme autodiff backend.
+// These are not read or written to by Rust code. They are required to survive
+// Link-Time Optimization (LTO) so that Enzyme can correctly identify them
+// as constant metadata variables when computing derivatives.
+#[unstable(feature = "autodiff", issue = "124509")]
+#[allow(non_upper_case_globals)]
+#[allow(missing_docs)]
+#[doc(hidden)]
+pub mod enzyme_globals {
+    #[unsafe(no_mangle)]
+    #[unstable(feature = "autodiff", issue = "124509")]
+    #[doc(hidden)]
+    pub static enzyme_const: u8 = 0;
+
+    #[unsafe(no_mangle)]
+    #[unstable(feature = "autodiff", issue = "124509")]
+    #[doc(hidden)]
+    pub static enzyme_out: u8 = 0;
+
+    #[unsafe(no_mangle)]
+    #[unstable(feature = "autodiff", issue = "124509")]
+    #[doc(hidden)]
+    pub static enzyme_dup: u8 = 0;
+
+    #[unsafe(no_mangle)]
+    #[unstable(feature = "autodiff", issue = "124509")]
+    #[doc(hidden)]
+    pub static enzyme_dupv: u8 = 0;
+
+    #[unsafe(no_mangle)]
+    #[unstable(feature = "autodiff", issue = "124509")]
+    #[doc(hidden)]
+    pub static enzyme_dupnoneed: u8 = 0;
+
+    #[unsafe(no_mangle)]
+    #[unstable(feature = "autodiff", issue = "124509")]
+    #[doc(hidden)]
+    pub static enzyme_dupnoneedv: u8 = 0;
+
+    #[unsafe(no_mangle)]
+    #[unstable(feature = "autodiff", issue = "124509")]
+    #[doc(hidden)]
+    pub static enzyme_primal_return: u8 = 0;
+
+    #[unsafe(no_mangle)]
+    #[unstable(feature = "autodiff", issue = "124509")]
+    #[doc(hidden)]
+    pub static enzyme_width: u8 = 0;
+}
diff --git a/tests/run-make/symbols-all-mangled/rmake.rs b/tests/run-make/symbols-all-mangled/rmake.rs
index 2cf579758002a..ec5924531f9f6 100644
--- a/tests/run-make/symbols-all-mangled/rmake.rs
+++ b/tests/run-make/symbols-all-mangled/rmake.rs
@@ -39,6 +39,10 @@ fn symbols_check_archive(path: &str) {
             continue; // Unfortunately LLVM doesn't allow us to mangle this symbol
         }
 
+        if name.starts_with("enzyme_") {
+            continue; // Enzyme metadata markers are allowed to be unmangled
+        }
+
         if name.contains(".llvm.") {
             // Starting in LLVM 21 we get various implementation-detail functions which
             // contain .llvm. that are not a problem.