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Electrostimulated VFA graph: separate observed outputs from predicted carbon-fixation mechanisms #1432
Review all five existing nodes and five arrows. Whole primary preprint main text was read from its public ResearchGate mirror; the canonical Research Square page returned 403. Treat sequential HRT changes and endpoint compartment differences cautiously. Computed pathway predictions cannot themselves cause acetate output; compartment composition used to predict pathways is not independent evidence for a causal arrow. Bulk IC loss and acetate are not an isotope-resolved mediation chain. Remove those three arrows; qualify HRT-to-composition and proposed architecture-to-IC removal. Remove categorical SYNTROPHY/CROSS_FEEDING and unsupported process annotations, and name only the three canonical representative taxa without implying a complete roster or necessity. Preserve observations, not stronger causal wording inherited from the source. No new graph structure.
Deduplication: 754 all-state issue titles/bodies, plus ignored/hidden-inclusive local review/research/history/tests/scripts/workflow search. Relevant #1164, #373, #1120 and #1121 read; #373 reused. Not every issue comment searched. No exact duplicate of these new findings in that scope.
Existing-graph defect addressed in #1437 at a22f0f8. Exact-head self-adversarial COMMENT: #1437 (review). 399 passed in 179.40s (0:02:59); actual post-commit docs-current passed. Three VFA arrows removed and two qualified; Arg/Met expansion remains pending under #1436. Close only after protected main merge. Other follow-ups remain open.
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realmarcin commentedon Oct 6, 2026
Existing-graph defect addressed in #1437 at a22f0f8. Exact-head self-adversarial COMMENT: #1437 (review). 399 passed in 179.40s (0:02:59); actual post-commit docs-current passed. Three VFA arrows removed and two qualified; Arg/Met expansion remains pending under #1436. Close only after protected main merge. Other follow-ups remain open.