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Arg-Met causal expansion: resolve heterogeneity and reporter-sensitivity mechanisms #1436

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@realmarcin

Ecoli_K12_MG1655_Arg_Met_CrossFeeding_Coculture.yaml, PMID:42592155.

The primary main body supports investigating new structure beyond the three existing nodes: reporter amino-acid sensitivity, manipulated nutrient/strain-ratio/spatial heterogeneity, and fluorescence CV. Separate direct perturbations from modeled diffusion/uptake and unresolved intrinsic/extrinsic noise. Do not import the different BL21-Priestia long-term evolution experiment or claim noise caused collapse.

One-community Edison causal dry run succeeded (11543 query characters; query SHA256 3436fd32f7df6cafd047bdeeebc44771d16606e56aca932689f3325786b001b5). No provider job or credits spent; a specific authorization request is pending. A source-based existing-node repair must leave this record needs_research, not reviewed, until this expansion is assessed. Primary snippets and canonical genotypes must be verified after any report; Edison output is a lead, not evidence.

Deduplication: 754 all-state issue titles/bodies, plus ignored/hidden-inclusive local review/research/history/tests/scripts/workflow search. Relevant #1164, #373, #1120 and #1121 read; #373 reused. Not every issue comment searched. No exact duplicate of these new findings in that scope.

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  1. realmarcin commented on Oct 6, 2026

    @realmarcin
    ContributorAuthor

    Existing-node corrections published in #1437, but this mechanism expansion remains OPEN and the record remains needs_research. Dry-run provenance recorded; no provider job submitted or credits spent. Specific spend authorization is pending.

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