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Qualify the Thermacetogenium formate energy-conservation mechanism #1888

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Description

@realmarcin

Finding

CommunityMech:000182 retains sound acetate-linked syntrophy, but its formate node and arrow present the 2019 proposed reverse-electron-transport mechanism as demonstrated. Distinguish measured enzyme/proteome evidence from unverified proton coupling and ATP-independent acetate activation. Do not erase the independent experimental support for formate involvement: the 2001 partner-comparison abstract reports faster PB/TM than PB/DeltaH conversion and low formate concentrations. Also keep the 2002 TM/PB methanogenesis expression result distinct from the separate DeltaH/butyrate system. Preserve both original directions with evidence-bounded wording.

Sources And Limits

https://pubmed.ncbi.nlm.nih.gov/15866934/
https://pubmed.ncbi.nlm.nih.gov/11872465/
https://pubmed.ncbi.nlm.nih.gov/31849917/
https://doi.org/10.1016/S1389-1723(01)80137-7

Both whole records and all existing graph snippets read. Fresh primary abstracts and Crossref identities retrieved for all six existing sources; 2019 full XML/main body read. Existing cached main bodies of the 2002 expression, 2005 pathway and 2006 phenotype papers read in full; fresh full XML retrieval returned HTTP500 and PMC browser retrieval challenged access. 1997 and 2000 sources are abstract-bounded. The 2001 formate partner-comparison abstract was read on the publisher site, not its full paper. Original figure pixels, supplements and raw data were not reviewed. No new publication bodies or caches will be committed.

All-state issue-title/body dedup and ignored/hidden-inclusive local path search recorded; matching #800 is unrelated. Local search excludes .git, generated docs/site, reference caches and .env files; it is not an exhaustive historical PR-comment review.

Lifecycle

Address in batch114; close only after protected-main merge. Self-adversarial review is not independent approval.

Activity

  1. realmarcin commented on Oct 8, 2026

    @realmarcin
    ContributorAuthor

    Graph repair addressed; close only after protected-main merge. #1892 at 62b18e2; self-review #1892 (review). 1033 passed in 414.10s (0:06:54); postcommit docs-current passed. Two append-only histories, 27 validation outputs and five mutation probes recorded. No new topology or Edison invocation in this batch; prior research extensions remain incomplete. Self-review is not independent approval.

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