PerturbVI analysis

Analysis code for PerturbVI: scalable inference of gene programs from single-cell CRISPR perturbation data.

Important

Software: github.com/mancusolab/perturbvi
Documentation: mancusolab.github.io/perturbvi
Data: doi.org/10.34728/FK2/TM9ELW

Analyses

• simulation: PerturbVI and GSFA benchmarks across the b, g, K and L sweeps, and the missing-target scenario.
• luhmes: PerturbVI fit and GO enrichment for the LUHMES screen.
• replogle: PerturbVI fit and figures for the large-scale K562 screen.
• rare_variant: ASD rare-variant enrichment.